Have you ever wondered what the key enzyme behind dopamine synthesis looks like in three dimensions? Enter tyrosine hydroxylase (TH), the rate-limiting enzyme that’s critical to the creation of dopamine. TH is a powerful tool for observing the nerve fiber bundles between dopaminergic neurons in the circuit, especially in mouse brains where it can be used to compare the quantity and state of dopamine in substantia nigra pars compacta to basal ganglia.
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